What is PeptiStrong? Peptides for Muscle Health

The Benefits of PeptiStrong™ Peptides

• Supports muscle strength recovery
• May support lean muscle growth
• Increases muscle protein synthesis
• Supports reduced muscle breakdown
• Enhances response to resistance exercise
• Reduced Myostatin expression

After the age of 30, muscle mass decreases on average 3-8% per decade.[1] Biochemical changes in aging muscle also commonly occur like greater levels of oxidative damage and reduced muscle protein synthesis.[1] This can have a negative impact on your performance in the gym and other aspects of daily life. Whether you’re trying to build muscle or maintain it, promoting an environment of positive muscle homeostasis is key. Generally, when someone thinks of promoting positive muscle homeostasis, they’ll focus on stimulating anabolism (growth) or preventing catabolism (breakdown). This is why amino acids, peptides, and protein have been staple items in sports nutrition for decades. Today, we’re going to focus on peptides.

Peptides are chains of around 2-50 amino acids bound together. Peptides play important physiological roles in the body. Peptides have diverse biological functions, the ability to cross cellular membranes, and display high levels of potency at their target sites.[2] Some examples of naturally occurring bioactive peptides in the body include collagen, glutathione, and insulin. Bioactive peptides have demonstrated their efficacy in impacting blood flow, metabolism, and immune function.[3]

PeptiStrong™ is a patent-protected ingredient of bioactive peptides isolated from fava beans. The peptides used in PeptiStrong™ were discovered utilizing computational techniques like artificial intelligence and machine learning. It's also a non-GMO ingredient that has self-affirmed GRAS (Generally Recognized as Safe) status. And it’s even been researched in pre-clinical and clinical studies

The effect of PeptiStrong™ on phosphorylated gene expression and tumor necrosis factor alpha (TNF-a) secretion was assessed using an in vitro study in murine skeletal muscle cells and human macrophages [4] . Additionally, using artificial intelligence, peptides within PeptiStrong™ were characterized and predicted for their ability to increase protein synthesis and reduce TNF-a secretion, these predicted peptides were then validated in vitro. The bioavailability and stability of these peptides were also assessed in the study. This bioavailability was measured based on how the peptides were able to survive upper gut digestion, their transport across the intestinal barrier, and their stability in human plasma. The researchers also found that the peptides were resistant to the stomach intestinal proteases, displayed good intestinal barrier transport, and remained stable in plasma following their in vitro experimentation.[5]

The efficacy of PeptiStrong was then evaluated on attenuating muscle waste in vivo in an atrophy murine mode. In the disuse atrophy murine mode, following 18 days of PeptiStrong™ treatment, the mice exhibited significant attenuation of muscle loss and increased expression of fast and slow twitch muscle fibers. At the cellular level, an upregulation of protein-synthesis-related genes was observed in the muscle tissue following treatment with PeptiStrong™. The researchers noted that food-derived hydrolysates including other protein hydrolysates of fava bean failed to show this level of efficacy in vitro. In this pre-clinical study, PeptiStrong™ administration showed efficacy for attenuating muscle atrophy through multiple mechanisms including the simultaneous reduction of inflammation and increase in muscle protein synthesis.[4]

A clinical study aimed to compare the impact of PeptiStrong™ on muscle mass and strength loss during limb immobilization in comparison to milk protein supplementation. Thirty young men were subjected to one-legged knee immobilization for 7 days followed by 14 days of recovery. The subjects were randomized into a 20 g PeptiStrong™ group or an isonitrogenous control milk protein group. The researchers found that PeptiStrong™ supplementation performed similarly to milk protein supplementation in modulating the loss of muscle size during short-term immobilization and its regain during remobilization. Interestingly, the researchers noted that significantly higher levels of muscle protein synthesis rates during the remobilization phase were observed in the PeptiStrong™ group.[6]

A second double-blind, randomized controlled study was conducted on 30 healthy male subjects. The subject's strength levels were tested and then they were administered either a placebo or 2.4 grams of PeptiStrong™ a day. On the 14th day of the study, delayed onset muscle soreness (DOMS) was induced in the subjects using resistance exercise. The strength recovery and fatigue of the subjects was measured (including blood samples) over the course of the following 3 days. The researchers found that PeptiStrong™ supplementation significantly improved strength recovery, restoration, reduced fatigue, and positively modulated markers related to muscle homeostasis. Of note, they observed significantly reduced myostatin expression following PeptiStrong ™ supplementation which supports an anabolic response following intense exercise.[7]

Which Cellucor Products Contain PeptiStrong™?

We use PeptiStrong™ in our P6 Ultimate formula.

Regain ultimate energy, strength, and performance with the enhanced testosterone support of P6 Ultimate. Featuring a powerful formula, P6 Ultimate helps you get results in and out of the gym with enhanced testosterone, increased muscle building, supports libido, and amplified pumps.

References

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804956/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830668/

[3] https://www.ncbi.nlm.nih.gov/books/NBK562260/

[4] https://www.mdpi.com/2072-6643/12/8/2274/htm

[5] https://www.sciencedirect.com/science/article/pii/S2665927121000216

[6] https://www.sciencedirect.com/science/article/pii/S0022316623025166?via%3Dihub

[7] https://www.mdpi.com/2072-6643/15/4/986